Junk DNA can trigger drug addiction

Chelovecheskiy organizm ustroyen takim obrazom, chto nekotoryye veshchestva mogut vyzvat' sil'nuyu zavisimost'. I, pomimo izuchennykh dannykh o vliyanii psikhostimulyatorov na razlichnyye neyromediatory i otdely nashey tsentral'noy nervnoy sistemy, soglasno zayavleniyu ekspertov Oksfordskogo universiteta i Afinskogo universiteta, v mekhanizmakh formirovaniya zavisimosti mozhet byt' povinna nasha DNK. Prichem, imenno ta yeye chast', kotoraya, kak schitalos' raneye, malo vliyayet na razvitiye cheloveka. A imenno, tak nazyvayemaya, «musornaya» DNK i yeye uchastok, kotoryy dostalsya cheloveku mnogo millionov let nazad ot drevnikh virusov. Po soobshcheniyu izdaniya Proceedings of the National Academy of Science, v mekhanizmakh razvitiya zavisimosti igrayet rol' fragment NK2. Soglasno dannym statistiki, nositelyami etogo fragmenta yavlyayutsya 5-10% naseleniya Zemli. Pri etom sredi narkozavisimykh protsent nositeley fragmenta NK2 dostigayet 30%. No kuda interesneye proiskhozhdeniye etogo uchastka DNK. Kak izvestno, genom cheloveka imeyet v svoyem sostave ogromnoye kolichestvo fragmentov DNK, kotoroye dostalos' nam ot retrovirusov. Nekotoryye predstaviteli etogo vida mogut peredavat' svoy geneticheskiy material nositelyu, tem samym smeshivayas' s yego DNK. No chelovecheskiy organizm vyrabotal sistemu zashchity ot takikh «vtorzheniy», prosto «perevodya» virusnyye chastitsy v te fragmenty, kotoryye ne schityvayutsya v protsesse zhiznedeyatel'nosti. Imenno oni naryadu s uzhe «nenuzhnymi» genami i sostavlyayut tu samuyu «musornuyu» RNK. Tak vot, izuchaya proiskhozhdeniye NK2, issledovateli prishli k vyvodu, chto «bespoleznyye» uchastki vse-zhe okazyvayut vliyaniye na razvitiye cheloveka. Kak zayavil odin iz avtorov issledovaniya doktor Gkikas Madzhorkinis, «My poluchili ubeditel'noye dokazatel'stvo togo, chto chelovecheskiye retrovirusy mogut byt' opasneye, chem kazhetsya. NK2 imeyet ochen' dolguyu istoriyu. V obnaruzhennykh drevneyshikh retrovirusakh NK2 igral vazhneyshuyu rol', chto pozvolyayet sdelat' vyvod o tom, chto NK2 davno «pronik» v nashu DNK i my mozhem tol'ko gadat', skol'ko yeshche zagadok skryvayetsya v nashem genome. Konechno, samo nalichiye NK2 ne delayet cheloveka zavisimym, odnako etot fragment yavlyayetsya odnim iz provotsiruyushchikh faktorov i yego nositelyam nuzhno byt' krayne ostorozhnymi.»Развернуть2165/5000The human body is designed in such a way that some substances can cause a strong addiction. And, in addition to the data studied on the effect of psychostimulants on various neurotransmitters and departments of our central nervous system, according to experts from Oxford University and the University of Athens, our DNA may be guilty of the mechanisms of dependence formation. Moreover, it is precisely that part of it that, as previously thought, has little effect on human development. Namely, the so-called “junk” DNA and its part, which a person inherited from millions of years ago from ancient viruses. According to the publication of the Proceedings of the National Academy of Science, a fragment of NK2 plays a role in the mechanisms of development of dependence. According to statistics, carriers of this fragment are 5-10% of the world's population. Moreover, among drug addicts, the percentage of carriers of the NK2 fragment reaches 30%. But the origin of this DNA is much more interesting. As you know, the human genome contains a huge number of DNA fragments, which we inherited from retroviruses. Some representatives of this species can transfer their genetic material to the carrier, thereby mixing with its DNA. But the human body has developed a system of protection against such "intrusions" by simply "translating" viral particles into those fragments that are not read in the process of life. It is they, along with already “unnecessary” genes, that make up the very “junk” RNA. So, studying the origin of NK2, the researchers came to the conclusion that the "useless" sites still have an impact on human development. As one of the authors of the study, Dr. Gkikas Majorkinis, stated, “We have received convincing evidence that human retroviruses can be more dangerous than they seem. NK2 has a very long history. In the most ancient retroviruses discovered, NK2 played a crucial role, which allows us to conclude that NK2 has long “penetrated” our DNA and we can only guess how many more mysteries are hidden in our genome. Of course, the very presence of NK2 does not make a person dependent, but this fragment is one of the provoking factors and its carriers need to be extremely careful.”

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